To start shooting in Warframe, you need to know the basic controls (default on PC):

- Left Mouse Button — Fire your primary or secondary weapon.
- Right Mouse Button — Aim (increases accuracy and allows shooting at longer ranges).
- F — Switch between primary and secondary weapons. Hold F to switch to melee.
- R — Manually reload your weapon (automatic reloading occurs when you run out of ammo).

When you aim, "Aim Glide" mode activates if you're in the air — this lets you shoot while slowly descending after a jump.