There are 36 achievements in the game and pretty much all of them can be earned during one playthrough. There are only two mutually exclusive achievements:

• True Hunter - Finish Game on Expert Difficulty
  
• I Know, I Know! - Finish the Tutorial

This is because there's no tutorial on Expert difficulty level, but it only takes few minutes and can be easily finished separately.
I would still recommend playing on lower difficulty level initially to familiarize yourself with the game.

These achievements are story related and can't be missed.

An Incarceri Stone was stolen from the Order's Treasury. We followed a lead to the city of Lichtenheim.

The Koshmaar abducted a city into his realm. We gave pursuit and helped one of the Maskwraiths. After, we encountered Gabriel, and Solomon ran after him. But we were separated.

Solomon's hurt. I must find a cure for him.


Gabriel double-crossed me, but I know where to find him now.


I have everything I need to face the Koshmaar.


Solomon is dead. He turned into a Maskwraith. Gabriel showed up, and we joined forces.


We saved the city, and Camilla. The Koshmaar is re-imprisoned. But so is Gabriel. It is a bittersweet victory.



Make a choice whether to fight or to deal with Koshmaar.


I got to the first Incarceri Stone. Made a choice. Was it enough to get rid of the Koshmaars once and for all?

These achievements, while being missable, are really easy to unlock. Simply play the game without skipping anything, using hints etc. Their descriptions are self-explanatory.


Finish the Tutorial.


Play the Prologue without skipping any cutscenes.


Play Chapter 1 without skipping any cutscenes.


Finish a single Hidden Object Puzzle without using the Hint button.


Finish all Hidden Object Puzzles without using the Hint button.


Play 4 Minigames in a row without skipping.


Play all Minigames without skipping.


Finish Game on Expert Difficulty.




Finish the last minigame in the game without the skip.

Find 3 hidden objects within 3 seconds.


This one is self-explanatory. It can be done together with "Step Lightly" during one hidden object scene.


Finish a Hidden Object Puzzle with less than 4 mistaps.


Self-explanatory, although description comes from the mobile version and mentions taps rather than clicks. It can be done together with "Triple Shot" during one hidden object scene.


Finish a Hidden Object Puzzle in less than 20 seconds.


There are five hidden object scenes where you need to collect a number of objects of the same kind (plants, pearls etc.). They're the best for this achievement as picking them up is really easy. They as follow:

1. Chapter 1: Greenhouse - Demoncap Mushroom (solution below)
   
2. Chapter 1: Greenhouse - Pigment Fruits
   
3. Chapter 2: Market Alley - Pearls
   
4. Chapter 2: Market Alley - Ice Cubes (solution below)
   
5. Chapter 3: Academy Yard - Herbs

Read all the newspapers at the Lichtenheim Train Station.

When you arrive at the Train Station, simply click the message board and then read all three newspapers on it.




Open the gate in the Garden without making a negative.


In order to get to the Cathedral you need to solve a puzzle which will unlock the gate. The pattern you find in the game is a negative, so don't simply copy it, but reverse it.




Win a Rune Battle Minigame against a Maskwraith without an error.


On several occasions you'll have to fight enemy minions. Combat is simple, you just need to select a pair of symbols which don't appear on enemy's side.


Finish the First Memory Mirror in less than 3 minutes.


You need to solve three puzzles based on the same mechanics. In this case you need put elements in their correct positions.




Finish the Second Memory Mirror in less than 3 minutes.

You need to solve three puzzles based on the same mechanics. In this case you need to rotate elements and put them in their correct positions.




Finish the Third Memory Mirror in less than 3 minutes.


You need to solve three puzzles based on the same mechanics. In this case you need to swap elements until they're in their correct positions.




Finish the Fourth Memory Mirror in less than 3 minutes.


You need to solve three puzzles based on the same mechanics. In this case you need to swap elements until they're in their correct positions.




Finish the Fifth Memory Mirror in less than 3 minutes.


You need to solve three puzzles based on the same mechanics. In this case you need to move elements until they're in their correct positions.



Solution:

1. B, C, D, E, A, B, C, D
   
   
2. D, E, F, C, D, A, B, C, D, A, F, E
   
   
3. D, A, B, C, F, D, E, F, A, B, C, D, G, F, A, D

Win the final rune battle without an error.


This is the same as "Flawless Victory", simply don't make any mistake when fighting in the final battle.


Find the first Collectible.


There are 30 collectibles in the game and finding one of them will unlock this achievement. Check the "All Collectibles" guide for a full list.


Find half of all Collectibles.


There are 30 collectibles in the game and finding 15 will unlock this achievement. Check the "All Collectibles" guide for a full list.


Find all Collectibles.


There are 30 collectibles in the game and finding all of them will unlock this achievement. Check the "All Collectibles" guide for a full list.

Read 30 in-game writings during your journey.

There are various documents in the game (more than 30, so you can miss some) which count towards this achievement. Simply click and read (by clicking on a zoomed-in document when your cursor turnes into question mark) everything you find. While the description mentions "writings", I was able to confirm that paintings count as well.

Below is a list of documents which I believe count towards this achievement. I'm not sure they all count, but during multiple playthrough the achievement unlocked at different moments. Checking them all will definitely grant it. I'm not including screenshots as it would take way too much space.

Prologue
1. Theater Entrance - Newspaper on the door.
   
2. Theater Entrance - Note on the door
   
3. Theater Roof - Note on the bag.
   
4. Backstage - Note on the monster after defeating it
   
5. Order Treasury - Description of the statues on the left.
   
6. Order Treasury - Description of the statues on the right.
   
7. Order Treasury - Letter in the bag of the unconcious knight.
   
   
   Chapter 1
   
   
8. Train Station - Newspaper on the message board.
   
9. Train Station - Newspaper on the message board.
   
10. Train Station - Newspaper on the message board.
    
11. Train Station - A note in the basket behind boxes with fireworks.
    
12. Train Station - A note in Solomon's suitcase.
    
13. Garden Square - A note on the greenhouse door.
    
14. Garden Square - Poster about cancelled show on the gate.
    
15. Cathedral Yard - Painting on the left.
    
16. Cathedral Yard - A note on the Cathedral door.
    
17. Greenhouse - A note on the table.
    
18. Greenhouse - Weedkiller recipe on the table.
    
19. Cathedral Ruins - In the box dug out in the greenhouse.
    
20. Cathedral Ruins - A recipe for red dye next to skulls.
    
21. Inner Sanctuary - Information on the altar.
    
    
    Chapter 2
    
    
22. Market Entrance - Puzzle solutions in Solomon's box.
    
23. Market Alley - Description of the lion statue.
    
24. Market Alley - In lions mouth.
    
25. Market Alley - In a hidden compartment in the lion statue.
    
26. Market Square - Next to Solomon's bottle after helping him.
    
    
    Chapter 3
    
    
27. Academy Hall - Four photos on the wall.
    
28. Operating Room - Gabriel's patient record in the safe.
    
29. Operating Room - Left side of the room with an open book (classes cancelled).
    
30. Library - Medicine recipe on the table (not in your inventory).
    
    
    Chapter 4
    
    
31. Hideout - A note on the book on the sarcophagus.
    
32. Hideout - A list with potential targets on the sarcophagus.
    
33. Hideout - A book "Ancient Book Spell".
    
34. Mansion - Painting of Camilla.

Move the ladder back, forth, back and forth again!


Click the ladder in the library several times to send it to the left and right couple times.


Win the last fight against the Koshmaar without failing.


Another achievement requiring you to not make any mistake during a battle.